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Cell locations for AQP1, AQP4 and 9 in the non-human primate brain.

机译：非人类灵长类动物大脑中AQP1，AQP4和9的细胞位置。

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The presence of three water channels (aquaporins, AQP), AQP1, AQP4 and AQP9 were observed in normal brain and several rodent models of brain pathologies. Little is known about AQP distribution in the primate brain and its knowledge will be useful for future testing of drugs aimed at preventing brain edema formation. We studied the expression and cellular distribution of AQP1, 4 and 9 in the non-human primate brain. The distribution of AQP4 in the non-human primate brain was observed in perivascular astrocytes, comparable to the observation made in the rodent brain. In contrast with rodent, primate AQP1 is expressed in the processes and perivascular endfeet of a subtype of astrocytes mainly located in the white matter and the glia limitans, possibly involved in water homeostasis. AQP1 was also observed in neurons innervating the pial blood vessels, suggesting a possible role in cerebral blood flow regulation. As described in rodent, AQP9 mRNA and protein were detected in astrocytes and in catecholaminergic neurons. However additional locations were observed for AQP9 in populations of neurons located in several cortical areas of primate brains. This report describes a detailed study of AQP1, 4 and 9 distributions in the non-human primate brain, which adds to the data already published in rodent brains. This relevant species differences have to be considered carefully to assess potential drugs acting on AQPs non-human primate models before entering human clinical trials.
机译：在正常的大脑和几种啮齿动物的脑病理模型中观察到三个水通道（水通道蛋白，AQP），AQP1，AQP4和AQP9的存在。关于灵长类动物大脑中AQP分布知之甚少，其知识对于将来旨在预防脑水肿形成的药物测试很有用。我们研究了非人类灵长类动物大脑中AQP1、4和9的表达和细胞分布。在血管外星形胶质细胞中观察到了非人类灵长类动物大脑中AQP4的分布，这与啮齿动物大脑中的观察结果相当。与啮齿动物相反，灵长类动物AQP1在星形胶质细胞亚型的过程和血管周围末端表达，主要位于白质和胶质母细胞中，可能参与水体内稳态。 AQP1还观察到神经支配着部分血管的神经元，表明可能在调节脑血流量中发挥作用。如啮齿动物所述，在星形胶质细胞和儿茶酚胺能神经元中检测到AQP9 mRNA和蛋白。但是，在灵长类动物大脑的几个皮质区域中的神经元群体中，AQP9的位置也有所增加。该报告描述了对非人类灵长类动物大脑中AQP1、4和9分布的详细研究，这增加了已经在啮齿动物大脑中发表的数据。在进入人类临床试验之前，必须仔细考虑这种相关的物种差异，以评估作用于AQPs非人类灵长类动物模型的潜在药物。

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